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Updated: Sep 10, 2025

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
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Published on: December 7, 2014

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生殖系Jak2-R1063H突变干扰正常的造血发育,增加血栓形成和白血病转变的风险

Veronika Zimolova1, Monika Burocziova2, Linda Berkova1

  • 1Laboratory of Cell and Developmental Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.

Leukemia
|August 21, 2025
PubMed
概括

这种JAK2- R1063H生殖基因变异增加了骨髓增殖性新生体 (MPN) 的风险,导致血栓并发症和白血病转变. 这项小鼠和MPN患者的研究突出了其临床意义.

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