相关实验视频

Updated: May 8, 2026

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

斑点抗核抗体模式作为癌症患者免疫相关不良事件的潜在预测因素

Hiroki Kohno¹, Masaaki Yanai^2,3, Miyu Nishigami²

¹Division of Respiratory Medicine and Rheumatology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan. hkohno@tottori-u.ac.jp.

International journal of clinical oncology

|August 22, 2025

概括

在接受免疫检查点抑制剂 (ICI) 的癌症患者中,先前存在的抗核抗体 (ANA) 水平和斑点 ANA 模式可以预测与免疫相关的不良事件 (irAEs). 这一发现可以改善患者对IRAE的风险分层.

科学领域:

免疫学
癌症学
生物标志物发现

背景情况:

免疫检查点抑制剂 (ICI) 提高癌症存活率,但可能导致与免疫相关的不良事件 (irAEs).
已存在的自身抗体,特别是抗核抗体 (ANA),是irAEs的潜在生物标志物,但之前的研究显示结果不一致.
特定的ANA染色模式对irAEs的预测价值仍然在很大程度上未被探索.

研究的目的:

在接受ICI治疗的患者中,研究基线自身抗体水平 (包括特定的ANA模式) 与irrAEs的发展之间的关联.
确定 ANA 标位和染色模式是否可以作为临床意义上的 irAEs 的预测生物标志物.

主要方法:

在接受ICI治疗的626名癌症患者中进行了回顾性观察研究.
评估基线自身抗体水平,包括ANA标位和染色模式.
使用后勤回归和ROC曲线进行相关性分析,以评估等级≥2的基线因子的预测值.

主要成果:

较高的ANA标位 (≥×40) 和斑点的ANA染色模式与2级以上的IRE风险显著相关.
结合ICI治疗也与更高的IRE风险相关.
通过AUC测量的预测性效果与使用高ANA标位或斑点ANA模式 (约2%) 的模型相似. 没有任何问题.

结论:

在接受ICI,特别是组合治疗的患者中,基线ANA标量和斑点ANA模式是显著的预测生物标志物.
综合性ANA检测可能有助于对患者的IRA风险进行分层.
这些发现可以为IRE提供个性化管理策略.

关键词:

抗核抗体免疫检查点抑制剂与免疫相关的不良事件有斑点的图案

更多相关视频

Simultaneous Distinction of Monospecific and Mixed DFS70 Patterns During ANA Screening with a Novel HEp-2 ELITE/DFS70 Knockout Substrate

Simultaneous Distinction of Monospecific and Mixed DFS70 Patterns During ANA Screening with a Novel HEp-2 ELITE/DFS70 Knockout Substrate

Published on: January 17, 2018

Monitoring PD-1-Blocking Antibodies Bound to T Cells Derived from a Drop of Peripheral Blood

Monitoring PD-1-Blocking Antibodies Bound to T Cells Derived from a Drop of Peripheral Blood

Published on: February 5, 2020

相关概念视频

Adaptive Mechanisms in Cancer Cells

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...

Antigens Involved in Adaptive Immunity

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.