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Updated: Sep 10, 2025

Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay
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揭示突变AR-LBD中的联结体诱导的构造变化:分子动力学的洞察力

Madiha Sardar1, Nadeem Ahmad1, Mamona Mushtaq2

  • 1H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.

Journal of chemical information and modeling
|August 22, 2025
PubMed
概括

雄激素受体 (AR) 突变可以将AR从对抗状态转变为对抗状态,从而降低前列腺癌治疗的疗效. 这项研究揭示了AR-LBD突变如何改变协活性剂相互作用,推动这种转变并提供新的治疗点.

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