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脊髓缺血再注射损伤诱导神经元缩

Lei Xie1,2, Hang Wu2,3, Qiuping He1,2

  • 1Department of Orthopedic Surgery, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.

Cell & bioscience
|August 22, 2025
PubMed
概括

脊髓缺血再注射损伤 (SCIRI) 通过降低ATP7B的调节和神经元中铜的积累来激活细胞死亡途径. 使用氨四胺抑制铜积累可以保护神经元并改善运动功能.

关键词:
ATP7B 的使用四聚酸盐铜离子体菌病脊髓缺血再注射损伤

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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