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Updated: Jun 6, 2026

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质瘤干细胞的内皮转分:文献综述

Andrei Buruiana1,2, Stefan Ioan Florian3,4, Alexandru Ioan Florian3,4

  • 1Department of Morphological Sciences-Histology, Iuliu Hațieganu University of Medicine and Pharmacy, 8 Victor Babes Street, 400012, Cluj-Napoca, Romania.

Acta neuropathologica communications
|August 22, 2025
PubMed
概括

瘤干细胞 (GSC) 可以转化为内皮细胞,这一过程受到瘤微环境和信号通路的影响. 这种内皮转化会影响质母细胞瘤的预后和治疗反应.

关键词:
内皮细胞瘤干细胞转变差异化血管生成模拟

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相关概念视频

Forced Transdifferentiation01:28

Forced Transdifferentiation

Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial transdifferentiation occurs...