在未经控制的2型糖尿病中对empagliflozin补充甲胺和sitagliptin补充甲胺治疗结果的比较评估:来自巴基斯坦的观察研究的结果
在PubMed上查看摘要
概括
此摘要是机器生成的。在2型糖尿病患者中,恩帕格利弗洛辛补充治疗改善了HbA1c,血清肌和eGFR. 与西塔格利补充治疗相比,这种联合治疗显示出更好的功能改善.
科学领域
- 内分泌学
- 药理学
- 肝脏病学
背景情况
- 没有控制的2型糖尿病 (T2DM) 需要联合抗糖尿病治疗.
- 添加新的药物增加了副作用的风险,需要进行风险效益评估.
- 目前的研究评估了empagliflozin和sitagliptin作为补充治疗方法.
研究的目的
- 在T2DM患者中评估empagliflozin加甲福林与西塔格利普丁加甲福林的临床和安全结果.
- 为了比较这两种联合治疗对血糖控制和功能的疗效.
- 评估empagliflozin和西塔格利普丁在T2DM治疗中的风险益处.
主要方法
- 这是一项为期3个月的探索性,观察性,横截面研究,涉及155名T2DM患者.
- 参与者被分为两个组:西塔格利普丁+美特福林 (n=79) 和恩帕格利弗洛辛+美特福林 (n=76).
- 在基线和随访时测量了生物化学参数 (HbA1c,血清肌素) 和估计的球膜过率 (eGFR).
主要成果
- 两组都显示出显著的HbA1c降低 (p<0. 001), 两组之间没有显著的差异 (p=0. 25).
- 这两组均显示血清肌素显著降低 (p=0. 002).
- 与西塔格利普丁+梅特福林相比,Empagliflozin+梅特福林的血清肌素降低幅度更大 (p=0. 01) 并且显著改善了eGFR (p=0. 001).
结论
- 作为对甲胺的补充治疗,恩帕格利弗洛辛在未控制的T2DM中改善了HbA1c,血清肌素和eGFR.
- 与西塔格利普丁相比,Empagliflozin在该患者队列中表现出更好的保护作用.
- 在T2DM治疗中,使用empagliflozin的联合治疗可以改善临床结果和患者的安全性.
相关概念视频
Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively...
Sulfonylureas are oral hypoglycemic agents utilized in treating type 2 diabetes. They are characterized by their unique sulfonylurea chemical structure. The family of sulfonylureas is divided into generations. First-generation sulfonylureas, including tolbutamide (Orinase), chlorpropamide (Diabinese), and tolazamide (Tolinase), trigger insulin release from pancreatic β cells and enhance peripheral tissues' insulin sensitivity. The second-generation members, such as glipizide...
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...

