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Updated: Sep 10, 2025

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids
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作为对抗奥西默蒂尼布肺癌治疗的有效策略,EGFR有助于表观遗传调节的脂体PROTAC

Dongyuan Wang1,2, Yajing Liu1,2, Ying Chen3,4

  • 1Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|August 22, 2025
PubMed
概括

一种新型的脂体蛋白分解向化母 (PROTAC) 药物GM- protac有效地降解了对osimertinib耐药的肺癌细胞中的突变EGFR. 在临床前模型中,这种方法针对EGFR依赖和绕道抵抗机制,显示出显著的瘤抑制与最小的毒性.

关键词:
在HDAC表观遗传调节脂肪体中的PROTAC肺癌 肺癌对奥西默蒂尼布的耐药性

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