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严重创伤性脑损伤患者的炎症指数的预后价值

Yongxiang Yang¹, Dongbo Zou¹, Chen Yin²

¹Department of Neurosurgery, The General Hospital of Western Theater Command, Chengdu, China.

Brain and behavior

|August 22, 2025

概括

在入院3天后测量的中性粒细胞与淋巴细胞比率 (NLR) 可以预测严重创伤性脑损伤 (sTBI) 患者的结果. 这种炎症标志物提供了一种评估STBI预后的新方法.

科学领域:

神经科学
血液学
危急护理医学

背景情况:

严重的创伤性脑损伤 (sTBI) 在预测患者的结果方面存在重大挑战.
炎症标志物越来越多地被认为是伤害后预后的重要因素.

研究的目的:

评估特异性炎症指数的预后值,包括中性细胞与淋巴细胞的比率 (NLR),血小板与淋巴细胞的比率 (PLR),淋巴细胞与单细胞的比率 (LMR) 和全身炎症指数 (SIIs).
确定这些血液学比率是否可以预测STBI患者的临床结果.

主要方法:

在治疗后1,3天和7天收集的118名STBI患者的临床和血液学数据的回顾性分析.
对SII,NLR,PLR和LMR的绝对值的计算
统计分析包括比较,相关和回归方法,使用ROC曲线和多变量后勤回归来评估预后值.

主要成果:

有不良结果的患者在1,3,7天呈现出更高的绝对白细胞和中性粒细胞数量,并在1天呈现出更高的单细胞数量.
在接受治疗后3天,中性细胞与淋巴细胞的比率 (NLR) 在不良结局组显著更高.
多变量逻辑回归和ROC分析确定了在3天后的NLR作为格拉斯哥结局量表 (GOS) 的独立预测因子.

结论:

在入院3天后计算的中性粒细胞与淋巴细胞的比率 (NLR) 显示了预测STBI临床结果的新,准确和客观的炎症指数的潜力.
在接受治疗后3天的NLR可以作为治疗严重创伤性脑损伤的早期预后的有价值工具.

关键词:

其他国家临床结果炎症指数严重的创伤性脑损伤

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