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Updated: Sep 10, 2025

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在皮肤新生体中编程死亡连接体1 (PD-L1) 的预后意义:系统性审查和元分析

Alireza Abdollahi¹, Emad Mehrtash², Bita Jafarzadeh¹

¹Department of Pathology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

International journal of surgical pathology

|August 22, 2025

概括

在皮肤癌中,编程死亡配体1 (PD-L1) 表达具有不同的预后价值. 虽然它没有显著影响整体存活率,但它预测梅克尔细胞癌的结果会更好,但在其他情况下会更糟.

科学领域:

癌症学
免疫学
皮肤病学

背景情况:

编程死亡配体1 (PD-L1) 是一种具有既定治疗和预后作用的免疫检查点分子.
在各种皮肤瘤中PD-L1的预后意义尚未完全理解,并且仍然存在争议.

研究的目的:

系统地评估PD- L1表达在不同皮肤瘤的总生存期 (OS) 和无病生存期 (DFS) 的预后值.

主要方法:

在PubMed,Scopus和Web of Science数据库中系统搜索到2025年3月的24项研究的元分析.
结果包括OS和DFS,根据瘤类型进行亚组分析.
使用I2统计数据和道图表来评估异质性和出版偏差.

主要成果:

总体而言,PD- L1表达与OS (HR=0. 89) 或DFS (HR=0. 86) 没有显著的相关性.
亚组分析显示在梅克尔细胞癌中改善了PD- L1表达 (HR=0. 39).
在黑色素瘤和皮肤状细胞癌中,PD- L1预测了更好的DFS,但在皮肤血管肉瘤和脂质腺癌中预测了更糟糕的DFS. 在状细胞癌中,PD- L1与淋巴结转移风险相关 (OR=5. 33).

结论:

皮肤瘤中PD- L1表达的预后影响高度特定于亚型.
在某些皮肤癌 (如梅克尔细胞癌) 中,PD-L1可能表明生存率有所改善,而在皮肤血管肉瘤和脂质腺癌等其他癌症中则预测结果较差.

关键词:

B7-H1抗原其他类型进行元分析预后情况皮肤新生病

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