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中等强度的有氧运动减轻了雌性小鼠周围血管脂肪组织的肥胖引起的变化
Teresa M Da-Re1, Guilherme A Dos Santos1, Luiza H Rossi1
1Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo, Brazil.
通过减少炎症和氧化应激,有氧运动训练改善了肥胖雌性小鼠的血管健康. 运动训练也缓解了细胞衰老,并恢复了胸部周围血管脂肪组织的抗收缩反应.
科学领域:
- 心血管生理学
- 肥胖研究
- 运动科学
背景情况:
- 肥胖与全身炎症,氧化应激和血管功能障碍有关.
- 周周血管脂肪组织 (tPVAT) 在调节血管度和健康方面起着至关重要的作用.
- 在TPVAT中细胞衰老可能导致肥胖引起的血管病理.
研究的目的:
- 研究有氧运动对肥胖雌性小鼠的炎症,氧化应激和细胞衰老生物标志物的影响.
- 在静止,训练,肥胖的静止和肥胖的训练雌性小鼠中评估TPVAT的形态和抗收缩反应.
- 确定有氧运动是否可以改善肥胖引起的TPVAT变化.
主要方法:
- 雌性C57BL6/JUnib小鼠被分为四组:久坐 (SD),训练 (TR),久坐肥胖 (OB-SD) 和训练肥胖 (OB-TR).
- 评估了血清生物标志物 (葡萄糖,瘦素,TNF-α,马隆迪甲基),TPVAT形态 (脂质液滴大小,脂蛋白含量) 和血管β- 银酶活性.
- 评估了tPVAT对血清素 (5-HT) 的抗收缩反应.
主要成果:
- 肥胖的静坐性小鼠表现出血清葡萄糖,素,TNF-α和马隆迪甲基的升高,tPVAT脂质滴的增加和脂蛋白的降低.
- 肥胖的静坐性小鼠显示血管β- 银酶活性增加,并改变了对5-HT的抗收缩反应.
- 肥胖小鼠的有氧运动训练 (OB-TR) 降低了血清勒素,TNF-α和马隆迪阿尔海德,降低了TPVAT脂质滴,增加了腺素,减弱了β- 银酸酶活性,并改善了对5-HT的血管反应.
结论:
- 肥胖导致TPVAT显著的表型变化,其特征是血管衰老,炎症,氧化应激和抗收缩功能失调.
- 有氧运动训练有效地减轻了肥胖引起的TPVAT的几种变化.
- 在肥胖的雌性小鼠中,运动部分恢复了tPVAT抗收缩反应,并减少了关键的循环炎症和氧化应激标志物.
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