牙周治疗对心血管风险生物标志物的影响:系统性审查
Oral health & preventive dentistry
|August 22, 2025
概括
非手术性牙周治疗 (NSPT) 改善心血管风险生物标志物,特别是在患有或没有糖尿病的患者中减少炎症和改善血糖控制. 这些发现支持将牙周护理纳入心血管风险管理策略.
科学领域:
- 牙周病和心脏病
- 系统性炎症和慢性疾病
背景情况:
- 牙周病和心血管疾病有共同的炎症途径.
- 从口腔转移的细菌有助于全身炎症.
研究的目的:
- 系统地审查非手术性牙周治疗对心血管风险生物标志物的影响.
- 评估对内皮功能,全身炎症,血栓形成和脂质/葡萄糖代谢的影响.
主要方法:
- 在PubMed,Cochrane图书馆和Scopus数据库中进行系统搜索 (2010年以后).
- 包括使用NSPT治疗中度至重度牙周炎的成年患者.
- 对所有研究进行偏差风险评估.
主要成果:
- NSPT显著降低了高灵敏性C反应蛋白 (hs-CRP) 和炎症性细胞因子 (IL-6,TNF-α).
- HbA1c水平降低,特别是在2型糖尿病患者中.
- 内皮功能改善,内皮微粒 (EMP) 减少;血管参数结果异质.
结论:
- 通过改善炎症和血糖控制,NSPT显示出临床相关性.
- 这些发现支持将牙周护理纳入心血管风险管理.
- 对脂质代谢和血管功能的影响需要进一步研究.
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