口腔微生物群:辐射损伤中的作用和治疗 (综述)
1Department of Cancer Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Immunotherapy, Chongqing 401336, P.R. China.
Oncology letters
|August 22, 2025
概括
辐射损伤会损害正常组织,影响生活质量. 本综述探讨了口腔微生物群如何影响各种RIs,建议微生物调节用于预防和治疗.
科学领域:
- 癌症学
- 微生物学
- 辐射医学
背景情况:
- 放射治疗有效控制恶性瘤,但会对周围的正常组织造成辐射损伤.
- 由于目前没有有效的预防或治疗策略, RI显著降低了患者的生活质量.
- 人们越来越认识到口腔微生物在发展各种RI类型,包括大脑,口腔和肺部损伤中的作用.
研究的目的:
- 阐明潜在的辐射伤害机制.
- 提供口腔微生物群与10种不同类型的辐射损伤之间的联系的全面概述.
- 通过向口腔微生物群来确定RI预防和治疗的新临床策略.
主要方法:
- 对辐射伤害和口腔微生物群的现有研究进行文献审查和综合.
- 分析口腔微生物组成与各种辐射诱导病理之间的机制联系.
- 在口腔微生物群中确定潜在的治疗点,以减轻辐射损伤.
主要成果:
- 口腔微生物群与多种辐射损伤的发病有关.
- 特定的微生物特征与辐射引起的损伤的严重程度和类型相关.
- 调节口腔微生物群是治疗辐射伤害的一个有希望的途径.
结论:
- 向口腔微生物群为预防和治疗辐射伤害提供了一种新方法.
- 了解口腔微生物和辐射效应之间的相互作用可以导致个性化干预.
- 对微生物调节的进一步研究可以显著改善放射治疗后的患者结果.
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