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伦瓦提尼布相关的非结核菌性肺病:一个病例报告
Qian Wang1, Lili Du1, Yiming Wang1
1Department of Respiratory and Critical Care Medicine Huangshan City People's Hospital Huangshan Anhui China.
Respirology case reports
|August 22, 2025
概括
一名患有肝癌的患者因Mycobacterium kansasii感染而发作咳. 停药改善了症状和肺部病变,突出显示了药物诱导的潜在感染.
科学领域:
- 肝细胞癌研究
- 传染病诊断
- 癌症药物的副作用
背景情况:
- 肝细胞癌 (HCC) 的治疗通常涉及向治疗,如伦瓦替尼.
- 伦瓦提尼布是一种多酶抑制剂,可能会产生各种副作用.
- 机会性感染可能发生在免疫受损患者或长期治疗患者中.
研究的目的:
- 报告一种罕见的 Mycobacterium kansasii 感染病例,该病例发生在接受 lenvatinib 治疗 HCC 的患者中.
- 调查伦瓦替尼治疗与非典型感染的发展之间的潜在关联.
- 描述这种情况下的诊断挑战和管理结果.
主要方法:
- 一个64岁的男性患有HCC治疗lenvatinib的病例报告
- 诊断包括支气管镜检查和洗液分析.
- 使用下一代测序 (NGS) 来识别病原体.
- 临床治疗包括药物停用和症状监测.
主要成果:
- 通过支气管检查进行的初始病原体检测结果为阴性.
- 下一代测序 (NGS) 确定了Mycobacterium kansasii的存在.
- 停用林瓦替尼导致咳和胸部紧张感显著改善.
- 随访胸部CT显示肺病变完全消失.
结论:
- 在接受伦瓦提尼布治疗的患者出现呼吸道症状时,应考虑感染Mycobacterium kansasii.
- 下一代测序 (NGS) 是诊断具有挑战性的感染的一个有价值的工具.
- 停止使用伦瓦替尼可能是治疗这种机会性感染的关键步骤.
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