母亲饮食对子女肠道细菌和自闭症谱系障碍的影响
Zilin Chen1, Xu Wang2, Yuchen Hu1
1Department of Pediatrics, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Frontiers in cellular neuroscience
|August 22, 2025
概括
母亲的饮食会影响肠道细菌,可能会增加后代自闭症谱系障碍 (ASD) 的风险. 专注于母体肠道健康的策略可能有助于预防自闭症.
科学领域:
- 神经科学
- 微生物学
- 儿童发育医学
背景情况:
- 自闭症谱系障碍 (ASD) 是一种复杂的神经发育状况,其原因尚不清楚.
- 肠道微生物对神经发育和宿主健康至关重要.
- 孕产妇的肠道失调可能会通过肠 - 胎盘和肠 - 脑轴影响后代的自闭症风险.
研究的目的:
- 审查母亲的饮食习惯对肠道细菌的影响.
- 探索肠道微生物变化与自闭症相关的机制.
- 提出预防自闭症的饮食策略.
主要方法:
- 关于母亲饮食,肠道微生物群和自闭症的文献综述.
- 肠-胎盘轴的分析和母乳养中的微生物传播.
- 免疫,神经递质和代谢物通路的探索.
主要成果:
- 母亲的饮食不良 (高糖/盐/脂肪,低纤维,超加工食品,酒精) 会对肠道细菌产生负面影响.
- 肠道微生物失调会影响免疫系统,神经递质和代谢物.
- 这些干扰与后代自闭症风险的增加有关.
结论:
- 母亲肠道细菌的组成是自闭症发展的潜在因素.
- 针对母体肠道健康的饮食干预可以提供ASD的预防方法.
- 需要对ASD的微生物-肠-大脑轴进行进一步的研究.
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