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营养补充剂对肉症的影响:系统性审查和元分析
Usman Mansoor1, Donna Edano2, Maaza Usman3
1Pediatric Emergency Medicine, Al Jalila Children's Speciality Hospital, Dubai, ARE.
Cureus
|August 22, 2025
概括
营养补充剂有望改善老年人的肌肉力量和骨肌肉质量指数. 然而,需要进一步的研究来证实这些对肌肉质量和功能的益处.
科学领域:
- 老年学与营养科学
- 肌肉生理和衰老
背景情况:
- 随着肌肉质量,力量和功能的逐渐丧失,萨尔科佩尼亚对老年人产生重大影响,增加残疾风险和降低生活质量.
- 关于营养补充剂治疗肉症的现有文献不一致,强调需要严格的系统审查和元分析.
研究的目的:
- 系统地审查和元分析营养补充剂对肉症进展的影响,重点关注肌肉质量,力量和功能.
- 评估各种补充剂的有效性,包括蛋白质,氨基酸,维生素D,肌酸,欧米茄-3和矿物质,用于管理与肉相关的问题.
主要方法:
- 在主要的电子数据库 (PubMed,Scopus,Cochrane图书馆等) 进行了全面的文献搜索. ) 的情况.
- 包括的研究重点是营养补充剂对皮症患者的肌肉质量和力量的影响.
- 后分析采用随机效应模型,评估出版偏差,方法质量 (Cochrane风险偏差2.0) 和证据确定性 (GRADE).
主要成果:
- 营养补充剂显著改善了握力 (p=0. 05) 和骨肌肉质量指数 (p=0. 02).
- 也观察到总脂肪量显著增加 (p=0. 04).
- 在骨肌量,尾肌量或步行速度方面没有发现显著差异. 补充剂和对照组的不良事件发生率相似 (p=0. 60).
结论:
- 营养补充剂在改善肉症患者的肌肉强度和骨肌肉质量指数方面具有潜在的益处.
- 证据的高度确定性支持掌握力和骨肌肉质量指数的发现,而步行速度的证据较低.
- 建议进行进一步的长期,多中心和纵向研究,以验证这些初步发现并确定最佳的补充策略.
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