疑似药物诱导的肝损伤与塞夫特里克松相关:一个病例报告
Allison D Zettwoch1, Okelue E Okobi1, Mercedes Millan1
1Family Medicine, Larkin Community Hospital Palm Springs Campus, Hialeah, USA.
Cureus
|August 22, 2025
概括
这份病例报告详细介绍了一名患者在服用 ceftriaxone后出现药物诱导性肝损伤 (DILI). 迅速停止治疗和支持治疗导致肝酶正常化,强调老年患者谨慎选择抗生素.
科学领域:
- 内部医学
- 药理学
- 老年病学
背景情况:
- 一位85岁的女性患有多种并发症,出现呼吸系统症状.
- 这位患者有过帕金森病,甲状腺功能障碍,充血性心力衰竭和阿尔茨海默病.
研究的目的:
- 报告药物诱导性肝损伤 (DILI) 的情况.
- 强调在老年患者中及时识别和治疗DILI的重要性.
- 突出遵守老年人处方指南和结构化的DILI评估.
主要方法:
- 临床病例介绍和管理层审查.
- 在抗生素治疗期间监测肝功能测试 (AST,ALT).
- 停止使用疑似致病剂 (塞夫特里亚) 并提供支持性治疗.
主要成果:
- 在Ceftriaxone开始使用后48小时内,阿斯巴酸氨酸转移酶 (AST) 和阿氨酸转移酶 (ALT) 显著升高.
- 终止了塞夫特里亚治疗,导致肝酶逐渐正常化.
- 支持性治疗和每日肝功能监测是有效的.
结论:
- 塞夫特里亚可能导致严重的药物诱导性肝损伤 (DILI).
- 迅速停止药物使用和支持性护理对于DILI的管理至关重要.
- 遵守老年人处方指南和使用DILI评估工具对于患者的安全至关重要.
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