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循环长非编码RNA:情绪障碍生物标志物研究的新前沿

Bhaskar Roy¹, Anuj Kumar Verma¹, Ellie Marie Hulwi¹

¹Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.

Genomic psychiatry : advancing science from genes to society

|August 22, 2025

概括

长非编码RNAs (lncRNAs) 是关键的表观遗传调节剂,与主要抑郁症 (MDD) 和双极性疾病 (BD) 有关. 血液中特定的lncRNAs的失调可以作为诊断和预测这些情绪障碍的治疗反应的生物标志物.

科学领域:

精神病学
遗传学
分子生物学

背景情况:

大型抑郁症 (MDD) 和双相情感障碍 (BD) 是复杂的精神疾病.
人们越来越认识到表观遗传失调是MDD和BD病理生理学的核心.
在情绪障碍中表观遗传适应不良的精确分子机制仍然不完全理解.

研究的目的:

对长非编码RNAs (lncRNAs) 在MDD和BD中的作用进行最近的临床研究.
突出 lncRNAs 作为潜在生物标志物的疾病特异性贡献.
探索外周血液中 lncRNA 失调对情绪障碍的临床意义.

主要方法:

临床研究的综合文献综述.
从MDD和BD患者的外周血液样本中分析lncRNA失调.
评估 lncRNAs 作为潜在的诊断,预后和预测生物标志物.

主要成果:

在MDD和BD患者的外周血液中,特定的lncRNAs受到调节.
这些 lncRNA 显示为疾病特异性生物标志物的潜力.
LncRNA失调与临床诊断,预后和治疗反应的预测有关.

结论:

LncRNAs正在成为情绪障碍的关键表观遗传调节剂.
周围血液中的LncRNA概况为MDD和BD的生物标志物开发提供了有前途的途径.
进一步研究 lncRNA 对于进一步了解和治疗情绪障碍至关重要.

关键词:

双极性疾病没有血.抑郁症表观遗传学在cRNA 情绪变化

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相关概念视频

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...