孕产妇血清度和孕期体重增加:系统性审查和元分析
Afsaneh Halili1, Mojgan Kazemzadeh2, Ali Ahmadieh-Khanehsar3
1Department of Intensive Care Unit, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran.
International journal of preventive medicine
|August 22, 2025
概括
和多基物质 (PFAS) 与整体妊娠体重增加没有显著联系. 然而,在孕前BMI较低的妇女中,更高的 perfluorononanoic acid (PFNA) 水平可能与更高的妊娠体重增加有关.
科学领域:
- 环境健康
- 生殖健康
- 毒理学
背景情况:
- 人类通过环境途径无处不在暴露于和多基物质 (PFAS).
- PFAS可以干扰调节体重平衡的细胞信号通路.
- 关于PFAS和妊娠期体重增加 (GWG) 的先前研究产生了相互矛盾的结果.
研究的目的:
- 系统地审查和对PFAS暴露与GWG之间的关联进行元分析.
- 调查特定的PFAS化合物与妊娠体重变化之间的潜在相关性.
主要方法:
- 根据PRISMA的指导方针进行了全面的元分析.
- 在主要的科学数据库中进行了广泛的文献搜索 (例如,Medline,Web of Science,Scopus).
- 包括2023年10月至2024年3月的数据,重点是英语研究.
主要成果:
- 在主要的PFAS (PFOA,PFOS,PFNA,PFHxS) 和GWG之间没有发现显著的总体关系.
- 在怀孕前BMI≤25的女性中,亚组分析显示PFNA水平较高与GWG增加之间存在显著的关联.
- 血液PFNA水平的翻倍与该小组平均GWG增加30克相关.
结论:
- 主要的PFAS似乎对整体GWG没有显著的影响.
- 在怀孕前BMI较低的孕妇中,PFNA可能与GWG增加有关.
- 建议进行进一步的大规模队列研究,以证实这些发现,并探索暴露持续时间的影响.
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