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基于虚拟现实严重游戏的精神分裂患者认知功能评估:前性非随机临床试验
Chenxin Wu1, Yu Zhuo2, Jianying Yu1
1Mental Health Center, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, China.
Frontiers in psychiatry
|August 22, 2025
概括
果实先驱是一款虚拟现实游戏,有效地区分精神分裂症患者的认知缺陷与健康个体. 这种高效的工具对认知评估具有很高的准确性和用户接受度.
科学领域:
- 神经科学
- 精神病学
- 人与计算机的交互
背景情况:
- 传统的神经心理测试对精神分裂症缺乏生态有效性和效率.
- 虚拟现实 (VR) 提供了一种解决认知评估这些局限性的新方法.
研究的目的:
- 验证VR游戏"果实先"在区分精神分裂症患者 (SZ) 与健康对照者的认知障碍方面的诊断实用性.
- 评估果实先作为认知评估工具的用户体验和可行性.
主要方法:
- 一项涉及107名参与者的横截面研究 (43名SZ,64名HC).
- 使用精神分裂症简要认知评估工具 (B-CATS) 和果实先驱的认知评估.
- 通过接收器操作特征 (ROC) 曲线评估诊断有效性;使用游戏体验问卷 (GEQ-Core) 和模拟器疾病问卷 (SSQ) 量化用户体验.
主要成果:
- 精神分裂症患者在B-CATS上表现明显较差.
- 在Fruit Pioneer的16个指标中,有13个显示出强大的区分能力 (AUC>0.7).
- 总游戏分数 (TGS) 实现了高诊断准确度 (AUC = 0.911,敏感度 = 83.72%,特异性 = 89.06%) 并与B-CATS分数相关.
结论:
- 果实先驱是一个有效的时间 (5分钟) 和生态有效的工具,用于精神分裂症的认知评估.
- 游戏表现出强大的辨别有效性和积极的用户体验,具有高沉浸度和最小的模拟器疾病.
- 进一步的研究应探讨其在不同人群中的临床效用及其与功能结果的关系.
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