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免疫器官:模拟和分析人类适应性免疫力的新兴平台

Tianlong Li1,2, Dingkun Peng1, Meng Yao1,2

  • 1State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang, China.

Frontiers in immunology
|August 22, 2025
PubMed
概括

新的体外免疫器官模型弥合了实验室研究和临床应用之间的差距. 这些先进的平台,包括免疫器官,提高了对适应性免疫和疫苗开发的理解.

关键词:
工程组织生物培养免疫性有机物免疫器官微流体芯片

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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