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Updated: May 7, 2026

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
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Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

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新型TNFRSF9变体的临床和功能特征,导致免疫失调,易发生EBV驱动的淋巴发育

Peiwei Zhao1,2, Kailan Chen3, Li Yang4

  • 1Precision Medical Center, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.

Frontiers in immunology
|August 22, 2025
PubMed
概括

TNFRSF9基因的新变异导致一种罕见的原发性免疫缺陷疾病. 这种缺陷会损害T细胞反应和B细胞免疫力,导致感染和淋巴增殖.

关键词:
在 AKT艾滋病毒病毒病在 NF-κB其他类型免疫缺乏症淋巴扩散

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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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