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有多少是"足够的"? 在儿科自然主义fMRI中考虑功能连接可靠性

Shefali Rai^1,2,3,4, Kate J Godfrey^1,2,3,4, Kirk Graff^1,2,3,4

¹Child and Adolescent Imaging Research Program, University of Calgary, Calgary, AB, Canada.

Imaging neuroscience (Cambridge, Mass.)

|August 22, 2025

概括

与成人相比,儿童功能连接 (FC) 需要更长的扫描时间来进行可靠的fMRI测量. 儿童需要近两倍的数据持续时间才能达到可比的FC可靠性,影响发育神经成像研究设计.

科学领域:

神经成像
发展神经科学
大脑连接

背景情况:

可靠的功能连接对于神经成像研究至关重要.
小儿功能磁共振成像 (fMRI) 存在诸如头部运动和短时间扫描等挑战.
在儿童被动观测fMRI中FC的可靠性尚不清楚.

研究的目的:

使用精确的fMRI数据,比较儿童和成人之间的FC可靠性.
调查扫描长度对儿童群体的CF可靠性的影响.
在各种被动观测条件下探索FC可靠性的差异.

主要方法:

使用了25名青春期前儿童和25名成年人的fMRI数据.
在4个会议中收集了每位参与者的2.8个小时的数据.
作为扫描长度和头部运动的函数,分析了FC测试的可靠性.

主要成果:

儿童需要比成年人更长的扫描时间 (24. 6分钟),以获得可比的FC可靠性.
头部运动部分解释了空间不均的可靠性差异.
即使在延长扫描时间的情况下,高运动儿童的可靠性也很差;观察到参与权衡.

结论:

儿童神经成像需要更长的fMRI扫描时间来进行强大的FC测量.
扫描长度和头部运动是影响儿科FC可靠性的关键因素.
研究结果为发育神经成像提供了最佳的研究设计,特别是在高运动队列中.

关键词:

功能连接的可靠性自然主义神经成像儿科研究设计精确的fMRI

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