治疗晚期状细胞癌:皮肤科医生的指南
Joshua Burshtein1, Todd Schlesinger2
1Dr. Burshtein is with the Department of Dermatology at the University of Illinois-Chicago in Chicago, Illinois.
The Journal of clinical and aesthetic dermatology
|August 22, 2025
概括
晚期皮肤状细胞癌 (cSCC) 的治疗具有挑战性. 像塞米普利马布和潘布罗利祖马布这样的免疫疗法对手术或辐射无法治疗的晚期cSCC具有前景.
科学领域:
- 癌症学
- 皮肤病学
背景情况:
- 皮肤状细胞癌 (cSCC) 是第二常见的皮肤癌.
- 晚期cSCC包括局部晚期 (laCSCC) 和转移性 (mCSCC) 形式,通常不适合手术或放射治疗.
- 新兴的免疫疗法,特别是PD-1抑制剂,为晚期cSCC提供了新的治疗途径.
研究的目的:
- 审查目前对晚期cSCC的治疗选择.
- 为优化患者护理制定治疗策略.
- 突出免疫治疗在治疗晚期cSCC中的作用.
主要方法:
- 使用相关关键词进行了全面的文献搜索.
- 包括的研究重点是晚期cSCC的治疗策略.
- 对手术,放射治疗和免疫治疗 (PD-1 抑制剂) 的文献进行了审查.
主要成果:
- 由于大小,位置和攻击性特征, 高度cSCC可能具有挑战性.
- 越来越多的证据表明,塞米普利马布和潘布罗利祖马布是晚期cSCC的第一线治疗方法.
- 了解免疫治疗不良事件对于管理治疗效益至关重要.
结论:
- 管理先进的cSCC需要多学科的团队方法.
- 塞米普利马布和潘布罗利祖马布是治疗未经手术或放射治疗的laCSCC和mCSCC的有效选择.
- 这一综述受限于现有的文献和不同的研究方法.
相关概念视频
Skin Cancer
4.5K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.5K
Cancer Survival Analysis
453
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
453
Clinical Applications of Epidermal Stem Cells
2.7K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.7K


