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Hong Jun Kim¹, Chul-Hoo Kang¹, Jay Chol Choi¹

¹Department of Neurology, Jeju National University Hospital, Jeju National University School of Medicine, Jeju, Republic of Korea.

Frontiers in neurology

|August 22, 2025

概括

针对性温度管理 (TTM) 没有改善基底动脉阻塞中风患者的结果. 这种干预与成功重血管化后的临床结果和肺炎风险增加有关.

科学领域:

神经学
心血管医学
危急护理医学

背景情况:

针对性温度管理 (TTM) 显示出改善前部循环中风患者的治疗结果.
在后部循环中风,特别是基底动脉堵塞中,TTM的有效性在很大程度上还没有得到研究.

研究的目的:

评估TTM在经过成功重血管化的急性基底动脉阻塞中风患者的临床疗效.

主要方法:

研究了一组患有急性基底动脉闭塞中风 (NIHSS ≥10) 和成功的再通道化 (TICI ≥2b) 的患者.
患者接受了至少24小时的机械呼吸,目标温度为36°C.
在TTM和非TTM组之间比较了临床结果,包括功能状态 (修改的兰金尺度),死亡率,ICU停留时间和安全性.

主要成果:

与非TTM组 (n=25) 相比,TTM组 (n=16) 在3个月后的临床结果明显较差 (12. 5% vs.
接受TTM的患者在ICU停留时间较长 (11. 0 vs 9. 0天,p=0. 007).
在TTM组中,肺炎的发病率明显高 (p=0. 004).

结论:

在成功重血管化后,TTM可能不会带来好处,并且可能会使急性基底动脉封闭的患者的结果恶化.
需要进一步的研究来了解TTM在后部循环中风管理中的作用.

关键词:

急性基底动脉封闭急性缺血性中风前部循环中风后部循环中风重新道化有针对性的温度管理

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