2020-2023年韩国Y280系H9N2低致病性禽流感病毒的演变和传播
Andrew Y Cho1, Tae-Hyeon Kim1, Heesu Lee1
1Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
Transboundary and emerging diseases
|August 22, 2025
概括
在韩国,Y280系H9N2禽流感病毒已经占主导地位,取代了Y439系. 它的遗传标记表明它有可能跨物种传播给哺乳动物.
科学领域:
- 兽医病毒学
- 分子流行病学
- 公共卫生
背景情况:
- 2020年在韩国首次发现Y280系H9N2低致病性禽流感.
- 在该地区,Y439系H9N2病毒的先前主导地位.
研究的目的:
- 调查韩国H9N2禽流感病毒的持续传播和进化动态.
- 评估新出现的Y280系H9N2病毒的抗原性质和潜在的动物感染风险.
主要方法:
- 在活禽市场和养殖场进行积极监测.
- 抗原映射以确定病毒相关性.
- 贝叶斯系动力学分析以推断起源和传播模式.
- 对哺乳动物适应标志物的基因组分析.
主要成果:
- 这种Y280系的H9N2病毒已经取代了Y439系, 现在在韩国占主导地位.
- 在Y280和Y439系之间存在显著的抗原分歧.
- 有证据表明从中国引入,并经常在LBM和农场之间进行病毒交换.
- 检测哺乳动物适应标志物和对人类酸受体的高亲和力.
结论:
- 在韩国,Y280系H9N2病毒构成了不断发展的威胁.
- 对跨物种传播到哺乳动物的可能性需要进一步调查.
- 持续的基因组监测对于监测H9N2的演变和动物感染潜力至关重要.
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