儿童烧伤中心的Candida auris感染:治疗和感染控制措施
Seval Ozen1, Belgin Gulhan1, Sabri Demir2
1Department of Pediatric Infectious Diseases, Ankara Bilkent City Hospital, Ankara, Turkiye.
Northern clinics of Istanbul
|August 22, 2025
概括
这项研究报告了儿童烧伤中心的两例Candida auris真菌病例,详细说明了治疗策略和感染控制措施. 有效的合作是应对这一全球性健康威胁的关键.
科学领域:
- 传染性疾病
- 医学真菌学
- 医院流行病学
背景情况:
- 由于鉴定难度,抗真菌耐药性变化和传染风险,Candida auris (C. auris) 是一个重要的全球健康问题.
- 在全球范围内,C. auris的医院爆发正在增加,需要强有力的感染预防和控制 (IPC) 战略.
- 儿童烧伤中心特别容易受到多抗药性真菌感染.
研究的目的:
- 描述两名被诊断患有C. auris真菌病的儿科患者的临床经验.
- 概述用于C. auris血流感染的抗真菌治疗方案.
- 详细说明在医院环境中实施的IPC措施,以控制C. auris的传播.
主要方法:
- 使用MALDI-TOFMS识别了C. auris的分离物.
- 使用微稀释 (BMD) 方法进行了抗真菌敏感性测试.
- IPC措施包括患者隔离,环境查和患者监测.
主要成果:
- 两名儿科患者发生了由C. auris引起的导管相关血流感染 (CRBSI).
- 治疗包括长期的抗真菌疗法,包括卡斯波芬金,米卡芬金,脂质体安福特B和伏利康.
- 实施的IPC措施成功阻止了C. auris的进一步传播,没有发现新的病例或环境污染.
结论:
- 临床微生物学实验室和IPC委员会之间的有效合作对于早期诊断和治疗C. auris感染至关重要.
- 迅速实施严格的IPC协议可以抑制C. auris在医疗机构的传播.
- 对C. auris真菌病的抗真菌治疗策略需要仔细考虑敏感性和临床反应.
相关概念视频
01:22Healthcare Associated Infections II: Preventive Measures
2.8K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.8K
01:25Transmission-based Precautions II: Airborne and Protective Environment
1.5K
Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
1.5K
01:22Burn Injuries
2.8K
Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
2.8K
01:26Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
4.4K
Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
4.4K
01:20Infection
8.7K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
8.7K
01:26Standard Precaution
2.2K
Standard precautions are the minimum infection control safeguards used while caring for all patients, irrespective of their disease condition. They help prevent the spread of common infectious microorganisms to healthcare workers, patients, and visitors in all healthcare settings.
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
2.2K