患有多发性骨髓瘤和自身造血干细胞移植的患者
Ufuk Demirci1, Ulku Korkmaz2, Elif Gulsum Umit1
1Department of Hematology, Trakya University Faculty of Medicine, Edirne, Turkiye.
Northern clinics of Istanbul
|August 22, 2025
概括
在多发性骨髓瘤 (MM) 患者中,造血干细胞移植导致肌肉质量损失,特别是在老年人中. F-18 FDG PET/CT可以评估与治疗相关的肉症,有助于肌肉保存策略.
科学领域:
- 癌症学
- 老年病学
- 放射学
背景情况:
- 随着年龄的增长,肌肉质量和质量下降,导致患病率和死亡率的增加.
- 多发性骨髓瘤 (MM) 的特征是骨受损,包括干细胞移植在内的治疗可能会影响肌肉健康.
- 评估MM患者的肉症对于了解治疗副作用和患者整体结果至关重要.
研究的目的:
- 研究自身干细胞移植 (ASCT) 对多发性骨髓瘤 (MM) 患者的麻症的影响.
- 评估CT和F-18FDG PET/CT成像在评估与治疗相关的肌肉数量和质量的有用性.
- 确定年龄对MM患者治疗诱导的肉症的影响.
主要方法:
- 包括接受一线治疗且符合ASCT条件的MM患者队列.
- 在ASCT之前和120天后获得F-18FDGPET/CT扫描.
- 使用CT和PET成像分析肌肉质量和代谢活动,并对年龄组进行比较 (≤60岁和>60岁).
主要成果:
- 在治疗后,两年龄组均观察到肌肉质量的显著下降 (p< 0. 001).
- 在60岁以上的患者中,年龄是影响肌肉质量的独立重要因素 (p=0. 001).
- 代谢评估显示,两年龄组的腰部肌肉区域发生了与治疗相关的变化 (p< 0. 001),而大腿部区域没有显著差异.
结论:
- 在MM患者中,自身干细胞移植与肌肉质量损失有关.
- 在MM患者中,F-18 FDG PET/CT成像可以用于评估疾病进展和肌肉健康 (肉症) 的双重目的.
- 在接受治疗的MM患者中,建议提高意识和有针对性的物理治疗,以控制和潜在地改善肌肉质量和力量.
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