有或没有抗生素的牙周再生手术后的早期愈合
Ewa Dolińska1, Małgorzata Pietruska1, Robert Milewski2
1Department of Periodontal and Oral Mucosa Diseases, Medical University of Bialystok, Poland.
Dental and medical problems
|August 22, 2025
概括
在指导组织再生 (GTR) 后的术后抗生素没有影响早期愈合,但在6个月后显著改善了牙周内膜缺陷的临床附着水平 (CAL).
科学领域:
- 牙周再生手术
- 指导组织再生 (GTR)
- 骨缺陷的治疗
背景情况:
- 指导组织再生 (GTR) 是有效的牙周缺陷.
- 膜暴露和污染是常见的GTR并发症.
- 系统性抗生素通常用于GTR后,但仍然存在争议.
研究的目的:
- 评估术后抗生素对早期愈合和患者发病率的影响.
- 评估除蛋白质的牛骨矿物质 (DBBM) 与原膜 (GTR) 加上抗生素对内缺陷的有效性.
主要方法:
- 41名骨内缺陷患者被随机分为两组:使用抗生素 (阿莫西西林) 的DBBM/ GTR和单独使用的DBBM/ GTR.
- 在1周和2周使用早期愈合指数 (EHI) 评估早期愈合.
- 临床附着水平 (CAL),探测深度 (PD) 和牙衰退 (GR) 在基线和6个月测量.
主要成果:
- 在这两组中,早期的治愈没有任何不良事件.
- 在抗生素组的95%和对照组的80%观察到初级关闭 (EHI).
- 这两组都显示出显著的CAL增长,但抗生素组具有统计学上显著的更大增长 (p=0. 010).
结论:
- 术后的阿莫西林在牙周再生手术后没有影响早期的伤口愈合.
- 与没有抗生素相比,系统性抗生素在6个月后显著提高了临床附着水平 (CAL).
- 这些发现表明术后抗生素在改善再生结果方面具有潜在的益处.
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