在急性缺血性中风后感染的患病率和因素:一个单中心的五年后期研究
Weny Rinawati1,2, Aryati Aryati3,4, Abdulloh Machin4,5,6
1Doctoral Program in Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya 60132, Indonesia.
Epidemiologia (Basel, Switzerland)
|August 22, 2025
概括
急性缺血性中风 (AIS) 后的感染很常见,主要是由K. pneumoniae等细菌引起的. COVID-19 大流行改变了感染模式和抗菌药物耐药性,凸显了早期消化不良检查等预防措施的必要性.
科学领域:
- 神经学
- 传染性疾病
- 微生物学
背景情况:
- 脑卒中后的感染显著恶化了患者的结果, 但亚洲人口数据仍然很少.
- 了解中风后感染的微生物环境对于有针对性的治疗至关重要.
研究的目的:
- 确定急性缺血性中风 (AIS) 后引起感染的病原体的细菌和真菌特征.
- 分析COVID-19大流行期间感染率和相关因素的变化.
主要方法:
- 在2018 - 2022年期间住院的599名AIS患者 (≥18岁) 的回顾性研究.
- 使用微生物培养作为感染确认的黄金标准.
- 多重物流回归分析了与感染相关的因素.
主要成果:
- 单独的病原体感染率为21. 4%,主要来自唾液.
- 常见的细菌病原体包括K. pneumoniae,大肠杆菌,A. baumannii和S. aureus;真菌感染很少见.
- 在COVID-19期间,抗菌素耐药性增加. 重症监护室和中风监护室减少了感染风险. 尿导管增加了风险 (非COVID),而类固醇,TPN和气管切除术具有保护性 (COVID).
结论:
- 在COVID-19时代,AIS后的感染率和风险因素发生了变化.
- 预防策略,包括早期食障碍查,对于减轻感染风险至关重要.
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