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迷香提取物:植物化学成分和消除多微生物生物膜的潜力 Candida albicans 和抗药性细菌

Tuana Mendonça Faria Cintra¹, Raquel Teles de Menezes¹, Lara Steffany de Carvalho¹

¹Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (ICT-UNESP), São José dos Campos 12245-000, Brazil.

Biotech (Basel (Switzerland))

|August 22, 2025

概括

迷香水醇提取物对抗多种耐药性感染具有潜力. 这种草药有效地减少了多微生物生物膜,为挑战微生物病原体提供了有希望的替代疗法.

科学领域:

药理学和微生物学
自然产品化学

背景情况:

多种药物耐药的微生物对全球健康构成重大威胁.
植物药物为抗药性感染提供了潜在的替代治疗方法.

研究的目的:

评估迷香水醇提取物 (RHE) 的植物化学成分和抗膜活性.
评估RHE对*Candida albicans*和多种耐药细菌*Acinetobacter baumannii*,*Klebsiella pneumoniae*,*Pseudomonas aeruginosa*的多微生物膜的疗效.

主要方法:

通过HPLC-DAD和GC-MS对RHE进行植物化学分析,包括黄,和生物活性化合物的鉴定.
确定抗氧化活性 (DPPH测定),最小抑制度 (MIC) 和最小杀菌度 (MMC).
使用MTT测定和统计分析 (ANOVA,Tukey,Kruskal-Wallis,Dunn测试) 评估RHE的抗膜疗效.

主要成果:

RHE含有大量的黄和,具有显著的抗氧化活性 (EC50=19.53μg/ml).
在RHE中发现了罗斯玛林酸和α-Pinene等生物活性化合物.
RHE显示出杀菌活性,并显著减少了多微生物生物膜 (高达69. 6%的减少,p < 0. 05),在*C. albicans* + *A. baumannii*方面表现优于.

结论:

迷香水醇提取物具有显著的抗菌和抗菌膜特性.
RHE是一种有前途的治疗候选药物,用于对抗多药耐药病原体引起的感染.
需要进一步研究RHE作为天然治疗剂.

关键词:

黄虫树 (Rosmarinus officinalis) 其他植物药物微生物耐药性多抗性细菌植物疗法多微生物生物膜

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