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瑞图西马布与吉兰-巴雷综合征的后续发展之间可能的关联:一个病例报告

Lilian Chen¹, Stephen Lee Yu², Nolan Holley¹

¹Department of Internal Medicine, West Virginia University, Morgantown, WV 26506, USA.

|August 22, 2025

概括

用Rituximab治疗的大B细胞淋巴瘤 (DLBCL) 患者可能会出现吉林巴雷综合征 (GBS). 早期识别这种Rituximab诱导的GBS对于迅速治疗和改善患者的结果至关重要.

科学领域:

神经学
癌症学
免疫学

背景情况:

血液性恶性瘤,如扩散型大B细胞淋巴瘤 (DLBCL),与吉林巴雷综合征 (GBS) 有关.
作为免疫调节剂的利图西马布是DLBCL治疗的关键成分,其使用正在增加.
需要对Rituximab诱导GBS的潜在临床意识.

研究的目的:

在患有DLBCL的患者中报告Rituximab诱导的Guillain- Barre综合征.
突出治疗Rituximab和GBS发病之间的时间关联.
强调识别这种不良事件对于及时管理的重要性.

主要方法:

案例报告的展示.
临床评估双边肢体疲弱的进展情况.
评估Rituximab完成和症状出现之间的时间关系.
对静脉注射免疫球蛋白 (IVIG) 治疗的反应评估.

主要成果:

一名60多岁的DLBCL男性患者在完成基于rituximab的治疗后6周内出现了渐进性的衰弱.
对IVIG的临床表现和反应证实了治疗诱导的GBS.
这一案例支持Rituximab与GBS发展之间的潜在关联.

结论:

在血性恶性瘤中增加的利图西马布使用需要对矛盾的GBS发展保持警.
及时诊断和治疗Rituximab诱导的GBS对于患者的良好结果至关重要.
了解这种关联有助于迅速评估和治疗受影响的患者.

关键词:

吉兰·巴雷综合征血液学神经学周围神经疾病其他药物

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