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评估VAMS Mitra微量采样器对全血微量元素分析的有效性

Oludesola Ogunesan¹, Christa Dahman Zaborske², Cassandra Newsom³

¹Department of Environmental Health Science, University of Alabama at Birmingham, Birmingham, USA.

|August 22, 2025

概括

体积吸收微样采集 (VAMS) 对生物监测具有前景,但在微样采集器中金属背景度较高时面临挑战. 清洁方案减少了一些金属,但持续的背景水平仍然是微量元素分析的限制.

科学领域:

环境健康
生物监测
分析化学

背景情况:

容量吸收微采样 (VAMS) 为金属和元素的生物监测提供了静脉穿刺的替代方案.
挑战包括微量样本中的高背景金属度和有限的血液体积.
这些限制对于环境健康和流行病学研究中的微量元素分析至关重要.

研究的目的:

评估VAMS对金属/元素生物监测的有效性.
评估和降低VAMS微样机中的背景金属度.
确定清洁方案对VAMS背景水平的影响.

主要方法:

通过VAMS和静脉穿刺收集的血液样本的微量元素分析.
使用诱导合等离子体质谱法 (ICP-MS) 来测量金属度.
实施和评估了VAMS微样机空白片的多步清洗方案.

主要成果:

最初的VAMS空白呈现出高背景金属度,有时超过静脉血液中的度.
在清洗后,某些元素的背景金属度下降.
然而,大多数检测到的金属在VAMS空白中仍然存在高度.

结论:

VAMS对环境健康和流行病学生物标志物研究有潜力,但存在重大局限性.
一个严格的清洁方案可以减少,但并不总是消除微样机尖端的背景金属度.
需要进一步优化,以克服使用VAMS进行敏感微量元素分析的背景度问题.

关键词:

容量吸收微采样背景度生物监测血液中的金属或微量元素儿童暴露的评估微量采样机

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