在儿童白血病患者中比较Calaspargase- Pegol和Pegaspargase的耐受性和毒性
Jinjoo Kang1, Srivarshini Kanukollu1, Angelica Bevinetto1
1Department of Pharmacy.
Journal of pediatric hematology/oncology
|August 22, 2025
概括
在儿童急性白血病患者中,卡拉斯帕加斯- 皮戈尔和佩加斯帕加斯的过敏性和失活率相似. 然而,卡拉斯帕加斯- 皮戈尔需要更多的治疗转换,并且患有较低的高 bilirubinemia.
科学领域:
- 儿童瘤学
- 药理学
- 血液学
背景情况:
- 卡拉斯帕加斯- 皮戈尔是治疗22岁以下急性白血病的标准长效阿斯巴拉金酶配方.
- 在儿童急性白血病中比较卡拉斯帕加斯-佩戈尔和佩加斯帕加斯的现实数据是有限的.
研究的目的:
- 在患有急性白血病的儿科患者中比较卡拉斯帕加斯- 佩戈尔的安全性和有效性.
- 评估过敏反应,无声失活以及与阿斯巴拉金酶相关的不良反应.
主要方法:
- 对103名患有急性白血病的儿科患者进行了回顾性评估.
- 治疗卡拉斯帕加斯- 皮戈尔 (n=50) 与佩加斯帕加斯 (n=58) 的患者的比较.
- 收集过敏反应,无声无声无声无声无声无声无声无声无声无声无声的无声无声无声的无声无声无声的无声无声无声的无声无声无声的无声无声无声的无声无声无声的无声无声无声的无声无声无声的无声无声无声无声的无声无声无声无声的无声无声无声无声的无声无声无声的无声无声无声的无声无声无声的无声无声无声
主要成果:
- 症状过敏反应的发生率 (20%对10. 3%) 和静态无活化 (16%对5. 2%) 均相似.
- 卡拉斯帕加斯- 皮戈尔需要更多的转化为短效阿斯巴拉金酶 (26%与10. 3%相比).
- 卡拉斯巴尔加斯- 皮戈尔的使用率较低 (34%对58. 6%).
结论:
- 卡拉斯帕加斯- 皮戈尔和佩加斯帕加斯在过敏和失活方面具有相似的安全性.
- 需要加大对卡拉斯巴加斯- 皮戈尔的监测,并可能转化为短效阿斯巴拉金酶.
- 需要进一步的策略来缓解与卡拉斯帕加斯- 皮戈尔相关的不良影响.
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