饮食脂肪与炎症性肠病发病风险增加有关:系统性审查和剂量反应元分析
Song Zhang1, Xiangyu Sui1, Jiahui Wei1
1Department of Gastroenterology, Changhai Clinical Research Unit, Changhai Hospital; National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, China.
International journal of surgery (London, England)
|August 22, 2025
概括
高脂肪摄入与炎症性肠病 (IBD) 风险的轻微增加有关. 然而,长链n-3多不和脂肪酸 (LCN-n-3) 和高的n3/n6比率可能会防止IBD发病.
科学领域:
- 胃肠病学
- 营养科学
- 流行病学
背景情况:
- 饮食中的脂肪与炎症性肠道疾病 (IBD) 的发生之间存在争议.
- 具体脂肪酸在IBD风险中的作用需要进一步阐明.
研究的目的:
- 调查和量化饮食脂肪摄入量与IBD发病风险之间的联系.
- 研究特定脂肪酸对IBD风险的影响.
主要方法:
- 在PubMed,Embase和Web of Science进行了系统的文献搜索,寻找到2025年1月的相关研究.
- 进行了元分析,子组分析,元回归和剂量反应评估,以组合相对风险 (RR) 和95%置信区间 (CI).
主要成果:
- 较高的总体脂肪摄入量与IBD发病风险增加存在轻微关联 (RR=1. 24).
- 多不和脂肪酸 (PUFA) 和胆固醇与更高的IBD风险有关,而长链n-3PUFA (LCN- n-3) 和高n3/n6-PUFA比率表明具有保护作用.
- 特定群体,包括亚洲,高男性比例和年轻人,表现出与脂肪相关的IBD的高度易感性.
结论:
- 脂肪摄入量增加可能与IBD发病风险的适度增加有关,特别是在PUFA和胆固醇方面.
- 摄入LCN- n-3和有利的n3/ n6- PUFA比率可能会降低患IBD的风险.
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