胰腺脂肪透及其与甘油三指数和冠状动脉化的风险之间的关联:多中心研究
Hao Zhou1, Xin Chen2, Yiping Zhang1
1Department of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China.
Clinical and translational gastroenterology
|August 22, 2025
概括
胰腺内脂肪沉积与冠状动脉化 (CAC) 有关. 将这种脂肪标志物与甘油三指数 (TYG) 结合起来,可以改善一般人群的CAC检测.
科学领域:
- 心血管疾病研究
- 代谢综合征研究
- 医学成像分析
背景情况:
- 胰腺内脂肪沉积与胰岛素抵抗和2型糖尿病有关.
- 胰腺内脂肪与冠状动脉疾病 (CAD) 之间的关系尚未得到充分研究.
- 冠状动脉化 (CAC) 是动脉样硬化和CAD风险的标志物.
研究的目的:
- 研究胰腺内脂肪沉积与CAC风险之间的关联.
- 评估胰腺内脂肪和甘油三指数 (TYG) 的综合预测值.
- 在接受肺癌查的一般人群中评估这些关联.
主要方法:
- 利用9479名接受肺癌查CT扫描的参与者的数据 (2018-2020年).
- 使用Ln[禁食葡萄糖 (mg/dL) ×禁食Tg (mg/dL) /2]计算了三糖 (TYG) 指数.
- 通过胰腺CT衰减评估胰腺内脂肪沉积,通过非心电图胸部CT评估CAC.
主要成果:
- 在9479名参与者中,有2447人 (25. 8%) 检测到CAC.
- 较高的胰腺CT衰减 (较少的脂肪) 与较低的CAC患病率相关 (Q4与Q1: 17. 8%与37. 8%,p < 0. 001).
- 胰腺CT衰减与TYG指数的结合显示出与单独的标志物相比,CAC的识别性能更好 (AUC为0. 646与0. 596和0. 612,p < 0. 001).
结论:
- 胰腺内脂肪沉积与CAC的存在有显著关联.
- 胰腺CT减弱和TYG指数的结合可以更好地识别CAC.
- 这些发现强调了使用胰腺内脂肪和TYG指数进行心血管风险评估的潜力.
更多相关视频
![Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F3777.jpg&w=3840&q=50)
10:02Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT
Published on: May 2, 2012
18.4K
11:30A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
2.1K
相关概念视频
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
119
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
119
01:24Chronic Pancreatitis I: Introduction
148
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
148
01:30Coronary Artery Disease I: Introduction
55
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
55
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
293
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
293
01:29Cholesterol: Significance and Regulation
678
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
678
01:24Obesity
612
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
612