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在山羊模型中,从出生到青春期的反动物生态系统形成中的微生物组与宿主共振模式

Jian Wu¹, Xiaoli Zhang¹, Zhiliang Tan¹

¹CAS Key Laboratory of Agroecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125, China.

Science China. Life sciences

|August 22, 2025

概括

皮

科学领域:

体微生物学
胃肠道的发展
主体与微生物群的相互作用

背景情况:

食动物的胃肠道成熟和微生物群对营养代谢和生产力至关重要.
膜粘膜是宿主微生物群相互作用的关键,但早期生命共振模式尚不清楚.

研究的目的:

描述从出生到90天的山羊的膜粘膜附着微生物群和宿主基因表达的动态变化.
阐明在生命早期发育的小肠微生物组与宿主上皮之间的共振模式.

主要方法:

在五个年龄组 (1~90天) 中分析了与乳头粘膜结合的微生物群落.
微生物组数据与宿主基因表达特征的整合.
膜粘膜的时间分析.

主要成果:

从第一天的曼海米亚 (Mannheimia),波菲罗莫纳斯 (Porphyromonas) 和链球菌 (Streptococcus) 到第10天的阿克尔曼西亚 (Akkermansia) 菌类 (muciniphila) 和乳杆菌 (Lactobacillus) 菌类 (amylovorus),最后到第90天的Succiniclasticum ruminis,Ruminococcus albus,Succinivibrio dextrinosolvens和Fibrobacter succinogenes,观察到主要细菌的变化.
膜粘膜表现出三个阶段的时间转移:消化系统的发育,免疫成熟和营养代谢.
确定了微生物群体与宿主上皮之间的特定相位相互作用,突出显示了早期消化/免疫发育和晚期营养代谢的不同作用.

结论:

rumen 粘膜中的微生物组与宿主共振在生命早期塑造 ruminal 生态系统中起着至关重要的作用.
了解这些动态对于优化反动物健康,生存和生产力至关重要.

关键词:

一只山羊微生物群微生物群与宿主之间的相互作用膜粘膜转录组

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