增加老年参与者的多样性:一个随机临床试验
Mireille Jacobson1,2, Doris Molina-Henry2,3, Tom Y Chang4
1USC Schaeffer Institute, University of Southern California, Los Angeles.
JAMA health forum
|August 22, 2025
概括
经济激励可以促进痴呆症临床试验的招生. 一个25美元的激励增加了参与,与彩票不同,特别是在白人和男性参与者中,提高了研究的多样性.
科学领域:
- 临床试验和痴呆症研究
- 健康差异和代表性
背景情况:
- 来自边缘化的种族,种族和社会经济群体的个体面临高痴呆风险,但在临床试验中代表性不足.
- 正在探索金融激励作为一种提高不同群体参与痴呆症研究的策略.
研究的目的:
- 评估财政激励对县卫生系统患者在记忆问题登记的影响.
- 评估不同激励结构在增加参与阿尔茨海默氏症预防试验 (APT) 网络研究中的有效性.
主要方法:
- 这是一项随机临床试验,涉及44844名年龄在50岁以上且未被诊断为痴呆症的患者.
- 参与者被分配一个标准的邀请,25美元的注册激励,或进入2500美元的彩票.
- 主要结局是招生,通过研究注册和认知评估的完成来定义.
主要成果:
- 共有401名参与者 (0.9%) 参与. 与没有激励措施相比,25美元的激励措施显著增加了入学率 (调整后的OR,1.39;P=.008).
- 彩票奖励没有显著增加招生人数 (调整后的OR,1.08;P>.99),并且显示招生人数低于25美元的奖励 (调整后的OR,0.78;P=.04).
- 25美元的奖励对白人患者 (调整后的OR,1.61) 和男性参与者 (调整后的OR,2.40) 最有效.
结论:
- 像25美元这样的小额奖励可以有效地增加痴呆症研究的招生人数.
- 基于彩票的激励措施效果不如小额支付的保证.
- 这一策略显示了提高经济多样性参与者的招生潜力,尽管需要进一步研究种族和民族多样性.
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