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Updated: Sep 10, 2025

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Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury
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儿科瘤患者的毒性和结局
Paulien A M A Raymakers-Janssen1,2, Nils Leitzinger3, Gerrit van de Berg4
1Department of Pediatric Intensive Care, Wilhelmina Children's Hospital/ University Medical Center Utrecht, Utrecht, The Netherlands.
概括
在儿童癌症患者中,急性损伤 (AKI) 是常见的,有37%的患者经历过这种情况. AKI显著增加患慢性病 (CKD) 的风险,强调在癌症治疗期间和之后需要谨慎监测.
科学领域:
- 儿童瘤学
- 肝脏病学
- 临床研究
背景情况:
- 急性损伤 (AKI) 是儿童癌症治疗的一个关键并发症.
- 在癌症治疗中使用的毒药物会增加AKI的风险,并可能导致慢性病 (CKD).
研究的目的:
- 在儿童癌症患者中确定AKI的发生率.
- 评估毒药物对AKI发展的影响.
- 调查AKI与随后的CKD风险之间的关联.
主要方法:
- 对1525名儿童癌症患者 (2015-2021) 的回顾性分析.
- 使用KDIGO标准进行AKI分类;一年后,CKD定义为eGFR<90mL/min/1.73m2.
- 用于评估 AKI 和 CKD 的风险因素的因果特异性危险和后勤回归模型.
主要成果:
- 37% 的患者患有 AKI; 确定了ifosfamide,amphotericin B,acyclovir 和 busulfan 作为危险因素.
- 年龄较大和切除术也与AKI风险增加有关.
- 在1年的随访中,13. 6%的患者患有CKD;之前的AKI发作显著增加了CKD风险 (一次发作为2. 6倍,多次发作为16倍).
结论:
- AKI在儿童癌症患者中普遍存在,是CKD的强烈预测因素.
- 需要密切监测高风险患者 (毒药物,多次AKI,之前的切除术).
- 实施从诊断到后期治疗的全面监测策略对于早期发现和干预至关重要,以防止AKI进展为CKD.
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