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创伤后血小板 - 淋巴细胞比率与肢体骨折患者的非结合:多中心回顾性队列研究

Chengsi Li¹, Zhenbang Yang¹, Puxin Yang¹

¹Department of Orthopaedic Surgery, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, People's Republic of China (PRC).

International journal of surgery (London, England)

|August 22, 2025

概括

创伤后血小板- 淋巴细胞比率 (PLR) 较低与骨折不结合的风险较高有关. 这一发现表明PLR可能是预测手术后骨愈合结果的生物标志物.

科学领域:

整形医学
创伤手术
生物标志物

背景情况:

创伤后的炎症和凝血会影响骨的愈合.
早期的血瘤和炎症可能会阻碍骨折的修复.
血小板- 淋巴细胞比率 (PLR) 和非结合之间的关联需要调查.

研究的目的:

在四肢骨折手术中量化血清PLR水平与术后非结合之间的关联.
探索PLR作为骨愈合结果的潜在生物标志物.

主要方法:

成人四肢骨折手术的回顾性多中心队列研究 (n=30,791) (2020年1月至2022年12月).
暴露:创伤后的PLR (血小板数 / 淋巴细胞数).
结果:骨折不合并 (定义为9个月以上未能愈合).
统计分析:受限立方线 (RCS) 和多变量逻辑回归.

主要成果:

在2. 1%的患者中发生非联合 (656/30,791).
在PLR和非联合风险之间发现了显著的负非线性剂量反应关系 (P非线性< 0. 001).
较低的PLR水平 (<145. 0) 与非联合风险增加有关 (调整后OR=1. 265,P=0. 010).
根据手术部位和固定方法观察到异质性.

结论:

创伤后PLR降低与骨折非结合的风险增加有关.
PLR可以作为一个有价值的风险分层生物标志物.
这些发现支持个性化干预计划.

关键词:

队列研究肢体骨折没有工会血小板和淋巴细胞的比例

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