通过早期断奶对胎儿进行编程,从而塑造了Nelore母牛的代谢型
Anjaleena Yaseen1,2, Ana Laura Dos Santos Munhoz Gôngora3, Thiago Kan Nishimura4
1Animal Sciences Division, Nuclear Institute for Agriculture and Biology College, Pakistan Institute of Engineering and Applied Sciences, Faisalabad, Pakistan.
PloS one
|August 22, 2025
概括
在肉牛中,早期断奶会改变血清代谢物和代谢途径,特别是在第二等数母牛中. 这影响了营养利用和代谢编程,为优化牛生产提供了洞察力.
科学领域:
- 动物科学
- 代谢学
- 生殖生物学
背景情况:
- 胎儿编程会影响后代的发育和新陈代谢.
- 孕产妇的平等性和生命早期的压力 (例如,早期断奶) 可以引起持久的代谢变化.
- 了解这些影响对于优化肉牛生产系统至关重要.
研究的目的:
- 研究早期断奶对Nelore母牛的血清代谢型的影响.
- 评估母体类别 (多胎与二胎) 和断奶策略对母牛新陈代谢的影响.
- 确定受这些因素影响的代谢途径.
主要方法:
- 一个2x2的因数设计,涉及母体类别和断奶策略 (EW与传统断奶 - CW).
- 使用1H-NMR光谱分析对55只Nelore公牛进行血清代谢分析.
- 使用PLS-DA,差异丰度和丰富分析的统计分析.
主要成果:
- 断奶策略的显著影响,母体类别,以及它们对血清代谢型的相互作用.
- 接受EW的二等母牛表现出谷氨酸,酸盐,酸盐和酸盐的增加.
- 来自多母的母牛具有较高的氨酸,肌酸和谷氨酸,这表明营养的可用性增加.
结论:
- 早期断奶对Nelore母牛的血清代谢类型和代谢途径 (能量,氨基酸,葡萄糖生成) 有显著影响.
- 孕产妇的平等性起着至关重要的作用,第二个平等性母体的后代在EW下表现出更明显的代谢转变.
- 在肉牛中改善新陈代谢效率和营养重新分配的潜力,尤其是在具有挑战性的条件下.
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