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腹透析患者的唾液微生物组:一个试点研究

Wararak Choovanichvong¹, Sirirak Supa-Amornkul², Dulyapong Rungraungrayabkul¹

¹Department of Oral Medicine and Periodontology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.

|August 22, 2025

概括

末期病 (ESKD) 显著改变了唾液微生物群,增加了细菌的数量. 麻症的影响很小,但勒普托里奇菌成为ESKD的主要唾液生物标志物.

科学领域:

微生物学
肝脏病学
口腔健康问题

背景情况:

末期病 (ESKD) 与全身性健康并发症有关.
肌肉质量的损失,经常与ESKD同时发生.
在慢性疾病中,口腔微生物群的变化越来越多.

研究的目的:

为了比较末期病 (ESKD) 和病 (SESKD),没有病 (NSESKD) 的患者和健康对照者的唾液微生物组成.
识别与ESKD和肉相关的潜在微生物生物标志物.

主要方法:

从33名参与者 (10名SESKD,12名NSESKD,11名对照人) 收集了唾液样本.
使用细菌16S rRNA基因测序 (V3- V4区域) 来分析唾液微生物组合.
评估了人口统计数据,口腔健康和肌肉力量.

主要成果:

与对照组相比,ESKD组 (SESKD和NSESKD) 的总体细菌数量显著增加.
唾液微生物组的组成因ESKD状态,教育水平和肌肉力量而有显著差异.
在ESKD患者中,Actinomyces和Atopobium的数量有所减少,而Actinobacillus,TM7x,Capnocytophaga,Neisseria和Leptotrichia的数量有所增加.
莱普托里希亚被确定为ESKD的潜在唾液生物标志物.

结论:

末期病对唾液的微生物组成有显著影响.
似乎对ESKD患者的唾液微生物群的直接影响很小.
莱普托里奇亚是检测ESKD的一个有前途的唾液生物标志物.

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