在静脉内注射抗VEGF后,角膜生物机械预测器的眼内压力升高
Sayaka Sumi1, Ryo Asaoka2, Shuichiro Aoki1
1Department of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
PloS one
|August 22, 2025
概括
角膜生物力学参数,特别是DA Ratio MAX,可以预测抗VEGF注射后的急性眼内压力峰值. 这有助于识别可能出现注射后血压升高的患者.
科学领域:
- 眼科 眼科
- 生物医学工程
- 角膜生物力学
背景情况:
- 静脉内抗VEGF注射是一种常见的视网膜疾病治疗方法.
- 在注射后可能会出现急性眼内压力升高.
- 预测这种内压升高对于患者管理至关重要.
研究的目的:
- 为了确定Corvis ST测量的角膜生物力学参数是否可以预测抗VEGF注射后急性内血压升高.
- 确定与内压峰相关的特定生物力学参数.
主要方法:
- 对40只接受抗VEGF治疗的眼睛进行了回顾性观察研究.
- 使用Corvis ST测量了注射前和后的内压.
- 评估的参数包括DA比率MAX (2mm) 和生物力学校正的IOP (bIOP).
主要成果:
- 平均内血压在注射后显著增加 (p < 0. 0001).
- 在55%的眼睛中,内压峰值≥10mmHg.
- 较低的DA比率MAX和较高的bIOP预测了内压升高;DA比率MAX预测了内压峰值 (p=0.035).
结论:
- 在注射抗VEGF后,DA Ratio MAX显著预测眼睛的适应性.
- DA Ratio MAX和bIOP可能有助于在注射前对与压力相关的并发症进行分层.
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