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Updated: Sep 10, 2025

Analysis of Simian Immunodeficiency Virus-specific CD8+ T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining
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Analysis of Simian Immunodeficiency Virus-specific CD8+ T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining

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在非人类灵长类动物中诱导的Apex表位的广泛中和抗体前体

Krystal M Ma1,2,3, Henry J Sutton1,4, Payal P Pratap1,2,5

  • 1Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.

Science immunology
|August 22, 2025
PubMed
概括

开发有效的艾滋病毒疫苗需要诱导广泛中和抗体 (bnAbs). 研究人员设计了一种HIV Env trimer,在非人类灵长类动物中成功引发了bnAb前体,这是疫苗开发的关键步骤.

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Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
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