相关实验视频
Updated: Sep 10, 2025
08:56
Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
Published on: April 7, 2023
985
宫内切除术,卵巢切除术和骨健康:系统性审查和分析
Md Shariful Islam1, Karen M Tuesley1, Louise F Wilson1
1School of Public Health, The University of Queensland, Brisbane, QLD, Australia.
European journal of endocrinology
|August 22, 2025
概括
双边卵巢切除会增加骨折的风险,而单独切除子宫会增加骨质疏松症的风险. 需要进一步研究以了解这些手术对骨健康的长期影响.
科学领域:
- 妇科和骨健康
- 手术成果研究
背景情况:
- 切除子宫和卵巢是常见的妇科手术.
- 这些手术对骨健康的影响,包括骨折和骨质疏松症风险,需要进一步阐明.
研究的目的:
- 系统地审查和元分析宫内切除术 (带或不带卵巢切除术) 与骨健康结果之间的关联.
- 评估这些手术后骨折,骨质疏松症和骨矿物密度 (BMD) 变化的风险.
主要方法:
- 通过全面的数据库搜索 (PubMed,Embase,Cochrane Central,CINAHL) 发现的研究的系统审查和元分析.
- 纳入标准集中在18岁以上的女性和检查子宫切除/卵巢切除和骨健康终点的研究.
- 在元分析中包括了19项研究,综合了来自15,000多篇选文章的数据.
主要成果:
- 双边卵巢切除显著增加骨折风险 (RR 1.17) 并显示出对骨质疏松症风险增加的无显著趋势.
- 没有卵巢切除的子宫切除与骨质疏松症的风险显著增加有关 (RR 1. 45).
- 与单独切除子宫相比,双侧卵巢切除并没有显示出更高的骨折风险;然而,研究的局限性包括异质性和缺乏详细的混变量评估.
结论:
- 双边卵巢切除与骨健康有负面关系,增加骨折风险.
- 切除子宫也可能增加骨质疏松症的风险.
- 进一步进行大规模的纵向研究对于完善关于手术范围,时间和药物使用的临床决策至关重要.
更多相关视频
07:20Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice
Published on: August 23, 2024
647
07:12Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
Published on: September 28, 2017
8.3K
相关概念视频
01:31Osteoclasts in Bone Remodeling
3.2K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.2K
01:29Bone Disorders
3.9K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.9K
01:40Bone Remodeling
38.5K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.5K
01:17Hormones and Bone Tissue
2.9K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.9K
01:25Role of Vitamins in Maintaining Bone Health
3.6K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.6K
01:31Essential Minerals for Bone Health
4.4K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
4.4K