坚持地中海饮食模式与克罗恩病患者的生化缓解有关
Lior Mor-Sasson1, Chen Sarbagili-Shabat2, Shiri Sherf-Dagan3
1Department of Nutrition Sciences, School of Health Sciences, Ariel University, Ariel, Israel.
Clinical nutrition (Edinburgh, Scotland)
|August 22, 2025
概括
坚持地中海饮食 (MD) 与克罗恩病患者的便calprotectin (FC) 水平较低有关.
科学领域:
- 胃肠病学与营养学
- 炎症性肠病研究
- 饮食干预措施
背景情况:
- 地中海饮食对克罗恩病患者来说是有前途的.
- 在活跃的CD期间,遵守MD可能是具有挑战性的.
- 这项研究调查了CD缓解中的MD粘附性和便calprotectin (FC) 变化.
研究的目的:
- 评估遵守地中海饮食 (MD) 与便calprotectin (FC) 水平的变化之间的关联.
- 在临床和生化缓解的克罗恩病 (CD) 患者中评估MD的坚持.
主要方法:
- 在临床和生化缓解 (HBI < 5,FC < 250μg/ g) 的96名克罗恩病患者中进行前性队列研究.
- 深度生化缓解定义为FC ≤150μg/g.
- 使用以色列地中海饮食选器 (I-MEDAS) 评估MD的遵守,中位数作为切断值.
主要成果:
- 基线MD的坚持与3个月后更高的深度缓解率有关 (87.5%对64.3%).
- 随着时间的推移,MD的坚持度有所下降.
- FC水平的变化与有害的MD成分的坚持有负相关性 (r = - 0.340,p = 0.006).
结论:
- 地中海饮食 (MD) 的坚持与基线和干预后3个月的便calprotectin (FC) 水平较低相关.
- 需要进一步的研究,以探索MD的长期影响,以维持克罗恩病 (CD) 的缓解.
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