在高脂肪饮食诱导的早期视网膜病变中,多组学分析揭示了肝视网膜轴
Xiaonan Zhang1, Mengxue Xia2, Yan Liu1
1Institute of Genome Engineered Animal Models for Human Diseases, National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, 116044, Liaoning, China; National Clinical Research Center for Eye Disease, Shanghai General Hospital, Eye Institute of Shanghai Jiao Tong University School, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Biochemical and biophysical research communications
|August 22, 2025
概括
高脂肪饮食可能导致糖尿病视网膜病变 (DR). 这项研究揭示了肝-视网膜连接,包括比如贝他因等代谢物和FGF21等因素,为早期DR提供了新的治疗点.
科学领域:
- 眼科 眼科
- 代谢疾病
- 分子生物学
背景情况:
- 糖尿病视网膜病变 (DR) 是与2型糖尿病 (T2DM) 相关的主要失明原因.
- 在全球范围内,高脂肪饮食正在增加T2DM,因此需要了解高脂肪诱导的DR病原体.
- 在饮食引起的视网膜病变中,肝视网膜轴的作用尚不清楚,特别是代谢物和分泌蛋白质的作用.
研究的目的:
- 研究高脂肪饮食引起的早期视网膜病变的分子机制.
- 探索肝脏与视网膜的交叉通话,并确定参与该途径的关键代谢物和因素.
- 发现饮食诱导的代谢压力相关的视网膜病变的潜在治疗点.
主要方法:
- 在使用高脂肪饮食的小鼠中诱导早期视网膜病变.
- 进行了视网膜和肝脏组织的RNA-seq数据的综合分析.
- 进行了新陈代谢和肝素分析以确定关键分子参与者.
主要成果:
- 高脂肪饮食导致视网膜病变, 视网膜杆缩短, 炎症增加,
- 在肝脏和视网膜之间观察到视网膜代谢和基因网络的协调变化.
- 特定的肝脏代谢物 (例如贝他因) 和因子 (例如FGF21) 与视网膜炎症发生共同变化,表明肝眼网络.
结论:
- 饮食引起的代谢压力建立了肝眼网络,导致早期视网膜病变.
- 确定了潜在的治疗点,包括贝他因和FGF21,用于早期DR的精确治疗.
- 提供了对代谢疾病并发症的远程器官调节网络的新见解.
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