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Updated: Sep 10, 2025

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高性金属间合金/碳纳米花纳米酶用于多模式协同癌症治疗

Yu-Lin Zhong¹, Bing-Bing Wang¹, Kai-Fei Chu¹

¹Key laboratory of the Ministry of Education for Advanced Catalysis Materials, College of Chemistry and Materials Science, College of Geography and Environmental Sciences, Zhejiang Normal University, Jinhua 321004, China.

Journal of colloid and interface science

|August 22, 2025

概括

一个新的纳米酶平台通过结合饥饿疗法,化学动力疗法,铁和化疗来克服瘤微环境的挑战.

科学领域:

生物医学工程
纳米技术
癌症学

背景情况:

化学动力疗法 (CDT) 的有效性受到瘤微环境 (TME) 的限制,特别是低水平的过氧化 (H2O2) 和高水平的谷氨酸 (GSH).
现有的纳米酶策略在克服TME对有效癌症治疗的限制方面面临挑战.

研究的目的:

开发一个多功能纳米酶平台,能够解决TME的局限性并增强癌症治疗.
整合多种治疗方式,包括饥饿疗法,CDT,铁和化疗,使其成为单一的纳米药物输送系统.

主要方法:

通过单步热解合成PtFeCoMoMn高金属间合金/N-化碳纳米花 (HEIA/NCNFs).
将HEIA/NCNF与葡萄糖氧化酶 (GOx) 和多克索鲁比辛 (DOX) 集成,以创建一个级联纳米治疗平台 (HEIA/NCNFs-GOx/DOX).
在体外和体内评估该平台的多酶类活性 (POD,CAT,OXD,GSHOx,NOX) 和治疗效果.

主要成果:

这些HEIA/NCNF显示出多种类似酶的活性,对TME调节和ROS生成至关重要.
级联纳米治疗平台成功产生H2O2,产生反应性氧物种 (ROS),耗尽GSH,并抑制GSH再生.
通过纳米酶系统的联合饥饿疗法,CDT,铁和化疗显著改善了乳腺癌治疗的疗效.

结论:

开发的级联纳米酶系统有效地克服了TME的局限性,提高了治疗精度并减少了非目标效应.
这种多功能纳米药物代表了开发安全有效的癌症治疗的有希望的进步.
这项研究强调了高合金和级联纳米酶在下一代癌症纳米疗法中的潜力.

关键词:

级联纳米酶催化铁症高性金属间合金反应性氧物种协同作用的癌症治疗

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