超磁刺激可以在放射性隔离综合征中发现早期皮质异常
Merve Bahar Ercan1, Evren Boran2, Emine Altin1
1Gazi University Faculty of Medicine, Department of Neurology, Ankara, Turkey.
Multiple sclerosis and related disorders
|August 22, 2025
概括
放射性隔离综合征 (RIS) 显示通过跨磁刺激 (TMS) 检测到早期的临床下脊髓和半球间功能障碍,这表明早期识别MS风险的潜力.
科学领域:
- 神经科学
- 神经学
- 生物标志物
背景情况:
- 放射性隔离综合征 (RIS) 是多发性硬化症 (MS) 的临床前阶段.
- 在RIS中显示出脱髓化病变.
- 超磁刺激 (TMS) 检测与脱髓和神经元损失相关的皮质脊髓功能障碍.
研究的目的:
- 使用TMS研究RIS中的运动皮质刺激性.
- 在RIS中探索TMS发现,认知,疲劳和MRI特征之间的关系.
主要方法:
- 16名RIS患者和16名对照患者接受了TMS,以评估RMT,MEP延迟,CMCT,CSP,SICI和SAI等参数.
- 通过SDMT评估认知功能;通过FSMC评估疲劳.
- 对TMS参数,认知,疲劳和MRI损伤负荷之间的相关性分析.
主要成果:
- 与对照组相比,RIS患者表现出长期的CMCT和iCSP,MEP延迟的趋势较大.
- 在RMT,CSP,SICI或SAI之间没有显著差异.
- 在RIS的参与者中,SDMT得分较低,FSMC得分较高.
- TMS参数与MRI病变特征没有相关性.
结论:
- 研究结果表明,在RIS中,早期的皮质脊髓和半球间功能障碍.
- 作为一种功能性生物标志物,TMS有望用于识别患MS转化风险较高的个体.
- 结合TMS和MRI可以提高早期的MS检测和风险分层.
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