相关实验视频

Updated: Sep 10, 2025

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

探索近视的潜在治疗点:因果分析和肠道微生物群的生物学注释

Zixun Wang¹, Yimeng Sun², Xiaoling Zhang³

¹Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.

Computational biology and chemistry

|August 22, 2025

概括

这项研究使用遗传数据将肠道细菌与近视联系起来. 某些细菌,比如Megamonas funiformis,可能会防止近视,而其他细菌,比如Bacillus velezensis,会增加患近视的风险,

科学领域:

眼科和微生物学
遗传学和生物信息学

背景情况:

眼睛近视是一种复杂的眼睛疾病,
肠道微生物群在近视发展中的作用尚不完全理解.
遗传因素影响肠道微生物组成和近视易感性.

研究的目的:

使用遗传仪器研究肠道微生物组成与近视之间的因果关系.
确定特定的肠道微生物对近视的潜在治疗价值.
了解肠道微生物与近视之间的联系.

主要方法:

使用全基因组关联研究 (GWAS) 总结统计数据进行双向双样本孟德尔随机化 (MR) 分析.
对473种肠道微生物群与近视相关的大型病例对照群的分析.
敏感性分析 (IVW,MR-Egger等) 和生物注释 (路径丰富,蛋白质相互作用网络) 来评估因果关系和机制.

主要成果:

15个微生物特征与近视有显著的因果关系.
保护类包括Dysgonomonadaceae家族和Megamonas funiformis.
与风险相关的分类包括Omnitrophota类和Bacillus velezensis.
宿主基因变异涉及PI3K-Akt和Ras信号通路.
由梅加莫纳斯衍生的短链脂肪酸 (SCFA) 抑制了PI3K-Akt/HDAC信号传递.
通过英多-3-乙/AhR激活,Prevotella massilia增加了氧化应激标志物.

结论:

肠道微生物群的组成会对近视的发展产生影响.
特定的微生物种群及其代谢物 (例如,SCFA) 是近视的潜在治疗点.
针对肠道细菌的微生物干预提供了一种新的近视治疗方法.

关键词:

生物注释肠道微生物群 (GM)孟德尔随机化 (MR)眼睛近视

更多相关视频

Inducement and Evaluation of a Murine Model of Experimental Myopia

Inducement and Evaluation of a Murine Model of Experimental Myopia

Published on: January 22, 2019

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Published on: April 3, 2016

相关概念视频

Microorganisms in Medicine and Therapeutics

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

Fungal Phylum Microsporidia

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...