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Lucas Freitas Carnevali¹, Luciana Wang², Milena Batista Sandrini Assugeni¹

¹Department of Oral Pathology, School of Dentistry, University of São Paulo, Brazil.

|August 22, 2025

概括

一名15岁的女性被诊断出一种罕见的牙性肉瘤,特别是乳腺纤维肉瘤. 手术治疗和BRAF V600E突变确认导致成功康复,没有复发.

科学领域:

口腔和面病理学
癌症学
遗传学

背景情况:

牙发育瘤是一个多样化的瘤群.
骨髓质纤维瘤是一种罕见的恶性口腔瘤,具有表皮和介质组分.

研究的目的:

在一个年轻的女性患者中报告罕见的肌肉纤维瘤.
突出诊断和治疗这种侵袭性瘤的挑战.

主要方法:

使用临床表现,成像 (CT/MRI),切口活检和组织病理学检查进行诊断.
对瘤组织进行了BRAF V600E的体质突变分析.
进行了切除和重建手术.

主要成果:

组织病理学发现一种类似于乳腺母细胞瘤的上皮成分和一种具有异型性和高线粒活性的瘤性介质成分.
这种瘤被证实为乳腺细胞纤维瘤,对BRAF V600E突变呈阳性.
在12个月的随访期内,手术治疗没有复发,也没有淋巴结转移.

结论:

骨髓质纤维瘤是一种侵袭性牙瘤,需要及时诊断和手术治疗.
在这种瘤的发病过程中,BRAF V600E突变可能起作用.
包括手术和康复在内的多学科管理对于有利的结果至关重要.

关键词:

年轻人 BRAF V600E 突变部新生体牙性瘤牙性瘤肉瘤

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